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Role of Antigen presenting cells Orally administered antigens can be acquired directly by M cells, macrophages, DCs and enterocytes [98], or can be delivered through goblet cell associated passages prior to capture by DCs in the lamina propria (LP), Peyers patches (PP) or MLN [99]

The goal is to maintain that critical 2-8C temperature range

Formation of disulfide bond in p53 correlates with inhibition of DNA binding and tetramerization

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