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Description
Weekly dosing maintains stable tissue levels of methyl donors and lipotropic compounds needed for consistent hepatic fat mobilisation less frequent dosing (biweekly or monthly) disrupts the methylation cycle and reduces efficacy significantly
Specifically, neomorphic mutations in the mammalian genes Isocitrate dehydrogenase 1 ( IDH1 ) and IDH2 result in the production of enzymes that inappropriately generate D-2HG from -ketoglutarate (KG)
J Trace Elem Med Biol
however, heroic surgical procedures are often required, so that cosmetic improvement may be debatable
