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Despite the limitations of multi-organ interactions, cell experiments are available for investigating cell-specific mechanistic pathways
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In summary, these findings demonstrate that GPR146 regulates adipose function in a stage-specific manner-promoting adipogenesis via Gq-PKC-AKT signaling during differentiation and stimulating lipolysis via ERK signaling in mature adipocytes-highlighting the context-dependent nature of GPR146-mediated metabolic control
MD analysis Interatomic distances, root mean square deviations (RMSD), root mean square fluctuations, and centroids were computed using VMD1.9.4 55
