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H., Zhang, B., Chen, D

Gut Microbiota-Derived Short-Chain Fatty Acids Facilitate Microbiota:Host Cross Talk and Modulate Obesity and Hypertension
205,206,207 Beyond this, GLP-1 exerts pleiotropic effects on multiple organs, including those involved in appetite control, whereas GIP directly influences metabolic processes in the endocrine pancreas and adipose tissue

Derek even said he was hesitant to first try it
