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Reduced sirtuin activity in an NAD + -depleted environment contributes, both indirectly via metabolic collapse and augmented fibrotic signaling, as well as by further inducing cellular senescence, to unchecked fibroblast activation and myofibroblast persistence driving intractable fibrosis

The full thymosin beta-4 molecule has been studied for its role in cell migration, angiogenesis, and wound repair (Goldstein et al., Expert Opinion on Biological Therapy, 2012)
