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Upon development of lung fibrosis following tracheal instillation of bleomycin, Gpx3 expression was observed in many more cells including bronchial epithelial cells and interstitial fibroblasts (Fig

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In addition to its role in metabolic tissues, some of the beneficial effects of PPAR ligands are due to anti-inflammatory actions, including inhibition of pro-inflammatory cytokines such as interferon gamma (IFN) and tumor necrosis factor-alpha (TNF) [53,54], increase of anti-inflammatory cytokines, and inhibition of inducible nitric oxide synthase (iNOS) expression

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