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Description
Tim-3 blocking rescue macrophage and T cell function against Mycobacterium tuberculosis infection in HIV+ patients
Reduce osteoclast activity and bone resorption markers Tartrate resistant acid phosphatase (TRAP): Inhibits TRAP activity by 40% -50%
This family acts as a "double-edged sword" in immune defense, cellular signaling, and oxidative stress [127]
Overexpression of TMEM106B has been reported to induce nuclear translocation of TFEB and expression of TFEB-regulated lysosomal genes in HEK293 cells, primary cortical neurons, and lung cancer cells [134, 148]
