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The IGF-1/PI3K/Akt signaling pathway is not only capable of activating anabolic pathways, but also of suppressing catabolic pathways, due to an inactivation of a specific transcription factor family called forkhead box-O transcription factors (FOXO) [53]

[DOI] [PMC free article] [PubMed] [Google Scholar] 136.Reimer M.K., Pacini G., Ahren B

doi: 10.1002/JLB.3MA1220-815RRR

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