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Patel T, Zhou J, Piepmeier JM, Saltzman WM

Kidney function highly depends of the homeostasis of this organelle, and mitochondria play a hub in signaling pathways, metabolic regulation, calcium homeostasis, and inflammation through the redox regulation, which also is important for the feedback communication with other organelles like endoplasmic reticulum (ER) and peroxisomes (MartnezKlimova et al

This anion then quickly breaks a disulfide bond and leads to Cys 63 nucleophilically attacking the nearest sulfide unit in the GSSG molecule (promoted by His 467 ) thus creating a mixed disulfide bond (GS-Cys 58 ) and a GS - anion