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But, we need more studies to know how well it works and the best dose

Inhibition of NNMT in adipose tissue led to smaller fat cells and reduced fat mass without affecting appetite or energy expenditure. Kraus et al., Cell Metabolism Enhanced Mitochondrial Energy and Endurance By increasing NAD, 5-Amino-1MQ supports mitochondrial function the energy engines of your cells

5-Amino-1MQ is studied in laboratory models involving NNMT pathway behavior, NAD-associated metabolism, cellular energy signaling, adipocyte-associated pathway activity, nutrient-response biology, and metabolic regulation

Severe B12 deficiency is widely reported and leads to pernicious anemia since your body needs B12 to make red blood cells, and a deficiency limits its capabilities to build them