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The stimulant effects of phentermine (increased heart rate, elevated blood pressure) combined with the cardiovascular changes produced by GLP-1 medications created a physiological profile that researchers flagged for further investigation

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Efficacy and safety of once-weekly cagrilintidesemaglutide (CagriSema) in adults with type 2 diabetes inadequately controlled on diet and exercise (REIMAGINE 1): a randomised, double-blind, placebo-controlled, phase 3a study, The Lancet Diabetes & Endocrinology, 14 , 8, (649-661), (2026)