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Conversely, inhibiting TLR4 can suppress microglial activation, alleviate neuroinflammation, improve cognitive function, and mitigate synaptic plasticity impairments and depression-like symptoms via this pathway (159, 160)

Biological and Pharmaceutical Bulletin , 31 ( 8 ), 16261630

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Wu X, Qian L, Liu K, Wu J, Shan Z
