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Coexpression of this variant with GRK2 in COS-7 cells resulted in a significantly decreased GRK-mediated phosphorylation and a complete attenuation of short-term desensitization (Small et al., 2001)

The DHS-led survival advantage of mice was accompanied by an increase in the total GPx activity as well as mRNA expression levels of seleno-GPxs ( GPx1 , GPx2 , GPx3 , and GPx4 ), reduction of lipid peroxidation, and suppression of inflammatory response (decrease of the expressions of pro-inflammatory genes and infiltration of inflammatory cells) in the radiosensitive organs such as spleen, intestine, and lung

When used at recommended dosages (typically up to 750 mg daily), it may occasionally cause minimal gastrointestinal side effects

10.1007/s12029-012-9378-1