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Interestingly, these IGF1R mutants with lower negative cooperativity in IGF1 binding showed slightly weaker activation in response to IGF1 (Fig

Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies

Mechanistically, the folate receptor-folate complex has been shown to internalize via a non-clathrin-mediated classical endocytotic pathway not involving lysosomes [5, 6]