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Description
They often appear weeks later during the healing phase, when pigment interacts with melanin, blood flow, and tissue regeneration
This may guide the identification of candidate metabolites, reveal the immune cell populations they influence, inform the selection of appropriate model systems for validations, and help disentangle local gut effects from systemic or tumour-specific effects, all within a clinically relevant patient setting
To date, contradictory results have been reported for autoantibodies as a major component in the pathogenesis of LC

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