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RSC Advances 6, 8143681446
This was achieved by improving the migration capacity of hMSCs towards damaged dopaminergic neurons and promoting their differentiation into dopamine-like neurons
This activity is initiated by the ten-eleven translocation (TET) enzyme family that includes TET1, TET2 and TET3
Subgroup analyses from KEYNOTE-177 showed no difference in PFS benefit between those with tumors harboring BRAF V600E mutations, a surrogate for MLH1 promoter hypermethylation in CRC, compared to sporadic tumors, although the study was limited by lack of germline data
