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Description
This binding is controlled by magnesium so that the calcium ions only flow in at the right time for the neuron to fire

Zhang K, Wong KP, Chow P

In type 2 diabetes [161] and sickle cell disease [162], The NLRP3 inflammasome has been reported to drive chronic low-grade inflammation by recognizing cytoplasmic mtDNA or mitochondrial ROS, recruiting the ASC adaptor protein and pro-caspase-1, and mediating IL-1/IL-18 maturation and cell death

[DOI] [PubMed] [Google Scholar] 30.Rahman I, MacNee W
