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A broad search was conducted combining key words and MeSH terms for PD, management options and outcomes of interest (Supplementary Information: Appendix A)

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Recent single-cell transcriptome studies have revealed several distinct microglia subpopulations and cellular states in aging and disease 1015 , including disease associated microglia (DAM) 12 , a presumably protective phagocytic microglia population, and neurodegenerative microglia (MGnD) 11 , a dysfunctional microglia phenotype
