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In addition to the effects of ethanol itself, its metabolitesacetaldehyde and acetatehave distinct neurological effects that may contribute to alcohols pharmacologic actions (140, 141)

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This mechanism plays a role in activating various downstream pathways, including RAS/MAPK, PI3K/AKT, Wnt/-catenin, and JAK/STAT, which are crucial for controlling a range of cellular physiological activities such as differentiation, proliferation, epithelial cell movement, angiogenesis, and EMT [21]