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Knockdown of mitophagy (a specific cellular process for elimination of dysfunctional mitochondria by autophagosome engulfment for subsequent lysosomal degradation) genes also reduced heat stress resistance in worms, due to increased protein aggregate formation caused by autophagy downregulation [118]
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Together, these data support the notion that stress-induced lifespan extension is likely a result of a cell-wide coordinated response, alongside robustly activated canonical HSR
CapZyme-seq comprehensively defines promoter-sequence determinants for RNA 5 capping with NAD
