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Description
PLP serves as a coenzyme in over one hndred enzymatic reactions, playing a crucial role in amino acid metabolism, neurotransmitter synthesis, gluconeogenesis, and lipid and carbohydrate metabolism
Erasmus JJ, Munden RF, Truong MT, Ho JJ, Hofstetter WL, Macapinlac HA, Correa AM, Wu TT, Bruzzi JF, Marom EM, Sabloff BS, Ajani JA, Komaki R, Liao Z, Lee JH, Fukami N, Bresalier R, Swisher SG

In vivo studies in iron-deficient mice confirm this: erythrocytes exhibit increased PS exposure, reduced glutathione (GSH) levels, and accelerated clearance, with these defects reversed by iron repletion ( 2+ homeostasis: non-selective cation channels in the RBC membranecritical for Ca 2+ entryare upregulated by iron depletion, possibly via ROS-mediated gating

Development of angiotensin IV analogs as hepatocyte growth factor/met modifiers
