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Although the rat GCLC promoter also contain a distal ARE 4 kb upstream [117], the 1.8 kb 5-flanking region of the rat GCLC does not contain any consensus ARE element (5-G/ATG/TAG/CNNNGCA/G-3) [105] and yet TBH treatment can induce the reporter activity driven by this 1.8 kb construct [118]

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Relugolix combination therapy maintained symptom relief over 52 weeks, with most patients showing no clinically significant decline in bone mineral density [163]

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