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Thereby, BPC 157 is easily applicable and safe without adverse effects (i.e., in ulcerative colitis trials) while toxicology studies showed that a lethal dose (LD1) can be not achieved (for review, see [1,2,3,4,5,6,7,8,9,10])
We have overcome the requirement to pattern hPSCs in a 2D format to definitive endoderm 3 by directly patterning in 3D pluripotent aggregates in suspension in an extracellular matrix (ECM)- and growth factor-independent manner
This is a clinical and medicolegal imperative
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