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57 Some patients may require a more frequent injection regimen, especially those with neurological symptoms, varying from twice weekly to every 2-4 weeks to become and remain asymptomatic

Insider's takeaway The Institute of Medicine has not established a tolerable upper intake level of B12 because studies show no adverse health effects when taking excess levels of B12, either through food or supplements

Brief exposure during transport (up to 2 hours unrefrigerated) is generally acceptable, but repeated temperature cycling degrades stability and should be avoided