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To test this, we synthesized two bromodomain and extraterminal (BET) ligands and two poly(ADP-ribose) polymerase (PARP1/2) ligands harboring JS-1 at previously established exit vector positions, none of which succeeded in degrading their targets (Extended Data Fig

First, the plasma membrane of the cell invaginates, forming a pocket around the target cargo [70]

These capsules are used in the management of various disease states such as Parkinsons disease, Alzheimers disease, and certain types of cancer

54: 46070 Greenberg MS, Wong H
