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This could also be validated in vivo in an EC-specific Pfkfb3 -deficient mouse model, demonstrating that the lack of Pfkfb3 results in decreased branch points and sprouts in a postnatal retina model (De Bock et al., 2013)

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FIGURE 3 4.1 Inflammation-driven pulmonary injury Circulating inflammatory cells are recruited and secrete inflammatory mediators, which communicate with structural cells (including epithelial cells, endothelial cells and fibroblasts) to trigger tissue inflammation and injury

Wang L, Wu X, Yang G, Hu N, Zhao Z, Zhao L, et al