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Similarly, sodium selenite-treated HT22 neuronal cells also had greater PGC-1 and NRF1 and greater mitochondrial proteins, cytochrome c and cytochrome c oxidase IV [Figure 2 ( During exercise, PGC-1 can be activated through two primary pathways: calcium (Ca 2+ ) calmodulin-dependent protein kinase IV (CaMKIV)/calcineurin A (CnA) and cAMP response element-binding protein [CREB
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