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[DOI] [PMC free article] [PubMed] [Google Scholar] Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, Bateman RJ, Holtzman DM, 2012

Conclusions This systematic review aimed to evaluate the effects of caffeine and related xanthines on neuroinflammation in rodent models of anxiety and depression

Substitution of key leucine residues (L145, L149, and L152) in the hydrophobic interface with tryptophan (1933 and 2007), significantly reduced peptide activity, indicating that these leucine residues are required for interaction with the hydrophobic pockets of FAT

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