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52 Another disc needle puncture study in mice has shown that 1 year after IVD degeneration induction, cold hypersensitivity (as indicator for radiating pain) persisted and was shown to be correlated with disc height, in a subset of the animals, whereas axial painbehaviors such as tail suspension and grip strength did not

Heres how it progressed: The first step was testing the drug in a small group of healthy adults

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YY and AC revised the manuscript