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In addition, a comprehensive list of 548 antioxidative stress genes were compiled from several sources: (1) Chromatin immunoprecipitation sequencing of NRF2 under basal and ROS-induced conditions as identified by Chorley et al

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This pathway has been implicated in several diseases including multiple types of cancers and cardiovascular diseases (178, 179)

For example, the current literature detailing the role of AMPK, the central sensor in response to the cellular energy state, remains controversial