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Taken together, these factors stabilize HIF- and prevent it from undergoing ubiquitination by E3 ligases (von Hippel Lindau factor, VHL ) for proteasomal degradation
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Studies indicate that cells will make a glycolytic switch when NAD + demand is high and exceeds ATP demand, therefore skewing the NAD + use for this pathway 341
Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human
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