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SAMe is a methyl donor involved in various methylation reactions in the body, including the synthesis of some neurotransmitters, such as dopamine and serotonin

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In people whose vitamin B 12 deficiency is related to overgrowth of intestinal bacteria, treatment with oral antibiotics such as tetracycline (sold under several brand names) may stop bacterial overgrowth and allow the absorption of vitamin B 12 to return to normal

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