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Description
Glutamate is an excitatory pronociceptive neurotransmitter associated with pain receptors

Circulating monocytes from RA patients produce elevated levels of IL-1 and IL-6 upon in vitro stimulation (69), IL-6 contributes to joint destruction (70), while IL-1 promotes osteoclastogenesis, induces matrix metalloproteinase (MMP) expression in chondrocytes, and initiates synoviocyte proliferation (71)

Moreover, ferrostatin-1 (Fer-1, 5 M), a well-established, ferroptosis-specific inhibitor, was included as a positive pharmacological control

To elucidate how Sororin interacts with the RAD21-SMC3 interface, we used AlphaFold3 to model the binding of a Sororin-CTR peptide to the interface formed by RAD21-NHD and SMC3-HD (Fig