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On the other hand, maintaining the pH of the formulations (especially liquid formulations) within the range of 4.5 to 6.5 ensures optimal drug permeation, minimises nasal irritation, and inhibits bacterial growth

Representative western blot images and quantification of s , liver, t , gastrocnemius, u , BAT and, v , iWAT of DIO mice treated with vehicle or 325 nmol/kg EB1002 18 h prior to injections with a mock solution or insulin (n = 5 (vehicle/mock), n = 6 (EB1002/mock, vehicle/insulin) n = 7 mice (EB1002/insulin))

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in multiple mouse models of obesity, this led to a decrease in body weight and the correction of dyslipidemia [141]