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During a state of deep rest, energetic demands are low, which enables mitochondria to repair and recalibrate through mitogenesis and other restorative processes

These advanced-stage therapies, targeting mechanisms such as amyloid and tau pathology, neuroinflammation, and synaptic protection, demonstrated promising efficacy and safety outcomes

Notably, overexpression of P53 gene is known to play a key role in reducing oxidative stress levels by, for instance, mediating enzyme activity of known ROS scavengers glutathione peroxidase (GPX) and aldehyde dehydrogenase (ALDH) [233]

The immune system responds to antigenic stimulation via dynamic shifts in lymphocyte subpopulations: B cells mediate humoral immunity, whereas CD4+ T cells serve as the commanders of the adaptive response