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All imaging was carried out with wide field microscopy

They state It is clear that serum thyroid hormone and thyroid stimulating hormone concentrations cannot be used with any degree of confidence to classify patients as receiving satisfactory, insufficient, or excessive amounts of thyroxine replacement The poor diagnostic sensitivity and high false positive rates associated with such measurements render them virtually useless in clinical practice Further adjustments to the dose should be made according to the patients clinical response. Similar results were observed by Meier et al

In the liver, FXR activation induces the small heterodimer partner (SHP), which inhibits SREBP-1c transcriptional activity, thereby repressing de novo lipogenesis

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