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Lv Q, Long J, Gong Z, Nong K, Liang X, Qin T, Huang W, Yang L (2021) Current state of knowledge on the antioxidant effects and mechanisms of action of polyphenolic compounds
The fragment contains a single intramolecular disulfide bond between Cys-7 and Cys-14
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The regulation of system X c /GSH/GPX4 axis in ferroptosis As the main antioxidant system against ferroptosis, the role of System X c /GSH/GPX4 axis is crucial in the treatment of various types of drug-resistant solid tumors, so an in-depth understanding of the regulatory mechanism of each node on this axis is of great significance for developing effective strategies for System X c /GSH/GPX4 axis targeted treatment of drug-resistant solid tumors (Figure 1)
