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these findings suggest that it prevents EMT from exerting its anti-fibrotic effects by affecting fibroblasts ( 3.5 Pneumonia In human lung epithelial cells (Calu3), andrographis paniculata extract and andrographolide exhibited strong anti-SARS-CoV-2 activity in a dose-dependent manner, with high safety and no obvious cytotoxicity (Zhu et al., 2013)