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Furthermore, the effects of GHK on astrocyte were associated with the upregulation of miRNA-146a-3p, which partially regulated the expression of AQP4

Epigenetic and MicroRNA Regulation In addition to genetic susceptibility, epigenetic modifications, such as DNA methylation, histone acetylation, and microRNA (miRNA) regulation, play critical roles in the pathogenesis of hypertension-induced kidney injury

Spatial omics now allow us to pinpoint the location of GPX4 cells, identify glycolytic versus OXPHOS niches, and visualize how these regions spatially align with, and suppress, infiltrating T cells

Yet, the top components only partially clustered subjects according to their respective groups suggesting strong interindividual variability ( Figure 2A )