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First, mitochondrial dysfunction manifests as the accumulation of mtDNA mutations [57, 58], disrupted energy metabolism [59], and elevated reactive oxygen species (ROS) production [60], severely affecting the energydependent substantia nigra dopaminergic neurons [61]

This action of CHAC1, known as the blocker of NOTCH, effectively reduces the cell surface expression of the full-length NOTCH1 receptor, thus inhibiting the NOTCH1 signaling pathway and contributing to the suppression of T-ALL cell viability ( 6.9 Melanoma Melanoma is a type of skin cancer that arises from the melanocytes, the cells responsible for producing melanin, the pigment that gives skin its color

Another example of the important role of D2 in development is the observation that D2KO mice have an impaired embryonic BAT development, and as a consequence a permanent thermogenic defect (102, 103)

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