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Importantly, the study confirmed that AOD-9604 displayed a very good safety and tolerability profile indistinguishable from placebo, with no treatment-related serious adverse events or study withdrawals occurring
The safety data for each compound individually is reassuring, but combination safety requires its own evaluation because pharmacological interactions can produce unexpected results even when each agent is well-characterized on its own
Skin elasticity presents another concern
Interestingly, the microbes deamidate NAM into NA, therefore bypassing salvage
