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There are multiple isoforms of merlin caused by alternate splicing 65, 72, 76, 155, but the predominant forms have tumor suppressor activity 21, 165
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Furthermore, the K55Q and E38K (HGVS: K77Q and E60K) mutations are much more common in individuals from African descent, which suggests a greater frequency of apoC-II deficiency in this population and less in the general population
Similar features are seen in Cav1 knockout mice [44]
