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As a state, a depressive mood may be an adaptive stress response ( Clinical response is usually noticeable after 25 weeks ( The difficulties in modeling depression and neuropsychiatric disorders in experimental non-human species may, in part, be attributed to the variability of depressive symptoms (across and within individuals), and the sheer impossibility to reproduce in non-human animals some important features, such as guilt and suicidality

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However, this procedure may be more beneficial for some groups of people, and for some, it may even be life-saving