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Diseases such as diabetes, hypertension, and atherosclerosis, among others, are associated with endothelial dysfunction and other major changes in the vascular function [8]

Twenty-five selenoprotein genes have been identified in the human genome including thioredoxin reductases (TXNRDs) and GPX4 [97,98]

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The mPFC, consisting of the prelimbic and infralimbic subregions, and the dorsal and ventral CA1 subregions of the hippocampus (dCA1 and vCA1, respectively), were removed bilaterally using 0.5 mm punches [89]