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The mechanisms of the effects of H 2 S on cell functions mainly include regulation of the activity of transcription factors, histone modification, DNA damage repair, DNA methylation, and post-translational modification of proteins through the sulfur hydration of H 2 S ( 2 S plays a vital role in multiple pathological and physiological processes, such as anti-inflammation (Mohammed et al., 2021), anti-apoptosis (Tocmo and Parkin, 2019), blood pressure reduction (Zaorska et al., 2019), and the regulation of cell survival/death, cell proliferation/hypertrophy and cell differentiation (Zhang et al., 2017)

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