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The data robustly suggest that despite its role in reducing the ERs GSHpool, CHAC1 does not influence the UPR, implying that GSHdepletion alone may not be sufficient to disrupt protein folding homeostasis to a degree that activates the UPR
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension
Further in vivo studies indicated that P
The delayed gastric emptying also enhances the incretin response, creating a complementary effect with GLP-1 based therapies
