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101 Despite major advances in the acknowledgment of tissue-specific NAD + homeostasis, further work will be needed to fully characterize the subcellular and systemic modulation of NAD + metabolism, which can improve the preventive and therapeutic strategies based on maintaining healthy NAD + homeostasis

208 Also, with repeated doses of cyclophosphamide, the plasma half-life of parent compound becomes progressively shorter, 196 , 209 and that of 4-hydroxycyclophosphamide increases, which indicates that cyclophosphamide can induce the P450 enzymes responsible for its metabolism

doi: 10.1007/s004210050356