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Vitamin B12 deficiency is common, especially if youre part of any of the groups below: People taking metformin for diabetes or long-term use of heartburn medication (antacid) Those following a strict vegan diet, including lactating women following a strict vegan diet and their infants breastfeeding exclusively People suffering from malabsorption disorders such as inflammatory bowel disease (IBS), celiac disease, certain pancreatic disorders Those who have had surgery that removed part of the small intestine where B12 is absorbed, such as weight-loss surgery People with decreased stomach acidity (common in people over the age of 50) B12 deficiency symptoms Symptoms associated with deficiency include: Anemia Dizziness Fatigue Shortness of breath Paleness Rapid heartbeat Muscle weakness and tingling in extremities Neurological symptoms such as memory loss, dementia, depression, and paranoia

Semaglutide's GLP-1 mechanism produces glucose-dependent insulin secretion alongside glucagon suppression, a profile characterised across the SUSTAIN program of clinical trials in type 2 diabetes anchored by the 2017 Sorli SUSTAIN-1 paper (PMID 28110911)